Luxury vacation homes inIsle of Palms, South Carolina

Our favorites

Discover luxury vacation rentals in Isle of Palms. All curated by people, not algorithms. Every property is hand-selected, but these are the ones that made us say 'wow'.

Our favorites

Discover luxury vacation rentals in Isle of Palms. All curated by people, not algorithms. Every property is hand-selected, but these are the ones that made us say 'wow'.

Premier

Charleston's coastal playground

Experience the coastal beauty of Isle of Palms, South Carolina from the comfort of a luxury vacation home. This Charleston-area barrier island combines pristine beaches, family-friendly atmosphere, water sports, and Lowcountry charm. Whether you're enjoying beach activities, exploring Wild Dunes Resort, or visiting nearby Charleston, premium KEY.co Isle of Palms vacation rentals provide the perfect family beach getaway.

Our curated selection of luxury vacation rentals in Isle of Palms offers something for every traveler - from beachfront properties with ocean views to modern homes near golf courses. Each rental home features thoughtful amenities, stylish décor, and the authentic Isle of Palms experience you're seeking. Discover why families love this welcoming destination while enjoying the privacy and comfort of your own vacation home on Isle of Palms' beautiful shores.